The PPARβδAgonist GW0742 Relaxes Pulmonary Vessels

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GW0742 is known to be an activator of PPAR-δ,19 and it can increase the expression of PPAR-δ 20 Therefore, GW0742 is widely used as an agonist

gw0742 GW0742 is a potent PPARβ and PPARδ agonist, with an IC50 of 1 nM for human PPARδ in binding assay, and EC50s of 1 nM, μM and 2 μM for human PPARδ,

gw0742 GW0742 is a potent and highly selective PPARβδ agonist, with IC50 of 1 nM, with 1000-fold selectivity over hPPARα and hPPARγ